Sunitinib
Cat. No.：YN440071
CAS No. ：557795-19-4
规格
价格(RMB)
库存
| 产品名称: | Sunitinib |
| CAS No.: | 557795-19-4 |
| Chemical Name: | |
| Synonyms: | 舒尼替尼; SU 11248 |
| 分子量: | 398.47 |
| 分子式: | C₂₂H₂₇FN₄O₂ |
| SMILES: | O=C(NCCN(CC)CC)C1=C(NC(/C=C2C(NC3=C\2C=C(C=C3)F)=O)=C1C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sunitinib (SU 11248) 是一种多靶点受体酪氨酸激酶抑制剂，抑制VEGFR2和PDGFRβ的IC50分别为 80 nM 和 2 nM。Sunitinib 是ATP 竞争性抑制剂，可通过抑制自身磷酸化和随后的 RNase 激活来有效抑制Ire1α的磷酸化。 |
| IC50和靶点: | [{name:"VEGFR2:80 nM (IC50)"},{name: "PDGFRβ:2 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
