SU16f
Cat. No.：YN440114
CAS No. ：251356-45-3
规格
价格(RMB)
库存
| 产品名称: | SU16f |
| CAS No.: | 251356-45-3 |
| Chemical Name: | 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid |
| Synonyms: | SU-16F,3-substituted indolin-2-one 16f,SU 16F |
| 分子量: | 386.44 |
| 分子式: | C₂₄H₂₂N₂O₃ |
| SMILES: | O=C(O)CCC1=C(C)NC(/C=C2C(NC3=C\2C=CC(C4=CC=CC=C4)=C3)=O)=C1C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SU16f 是有效的，选择性PDGFRβ抑制剂，对 PDGFRβ，PDGFR1，PDGFR2 的IC50分别为 10 nM，140 nM，2.29 μM。SU16f 抑制 PDGFRβ 受体从而可以阻断胃癌来源的间充质干细胞 (GC-MSC) 条件培养基在胃癌细胞增殖和迁移中的促进作用。 |
| IC50和靶点: | [{name:"PDGFRβ:10 nM (IC50)"},{name: "PDGFR2:140 nM (IC50)"},{name: "PDGFR1:2.29 μM (IC50)"}] |
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| Solvent & Solubility: |
Sun, L., Tran, N., Liang, C., et al.Design, synthesis, and evalutaions of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinasesJ. Med. Chem.42(25),5120-5130(1999)
Cao, N., Huang, Y., Zheng, J., et al.Conversion of human fibroblasts into functional cardiomyocytes by small moleculesScience352(6290),1216-1220(2016)
