CP-673451
Cat. No.：YN440188
CAS No. ：343787-29-1
规格
价格(RMB)
库存
| 产品名称: | CP-673451 |
| CAS No.: | 343787-29-1 |
| Chemical Name: | 1-[2-[5-(2-methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine |
| Synonyms: | CP 673451; CP673451 |
| 分子量: | 417.50 |
| 分子式: | C₂₄H₂₇N₅O₂ |
| SMILES: | NC1CCN(C2=C3N=C(C=CC3=CC=C2)N4C=NC5=CC(OCCOC)=CC=C54)CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CP-673451 是一种有效的，选择性的血小板源生长因子受体 (PDGFR) 抑制剂，抑制 PDGFRα 和 PDGFRβ 的活性，IC50值分别为 10 和 1 nM。 |
| IC50和靶点: | [{name:"PDGFRα:10 nM (IC50)"},{name: "PDGFRβ:1 nM (IC50)"}] |
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| Solvent & Solubility: |
Roberts, W.G., Whalen, P.M., Soderstrom, E., et al.Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451Cancer Res.65(3),957-966(2005)
Xi, Y., Chen, M., Liu, X., et al.CP-673451, a platelet-derived growth-factor receptor inhibitor, suppresses lung cancer cell proliferation and migrationOnco Targets Ther.7,1215-1221(2014)
Ehnman, M., Missiaglia, E., Folestad, E., et al.Distinct effects of ligand-induced PDGFRα and PDGFRβ signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartmentsCancer Res.73(7),2139-2149(2016)
