Ilorasertib hydrochloride
Cat. No.：YN440358
CAS No. ：1847485-91-9
规格
价格(RMB)
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| 产品名称: | Ilorasertib hydrochloride |
| CAS No.: | 1847485-91-9 |
| Chemical Name: | |
| Synonyms: | ABT-348 hydrochloride |
| 分子量: | 525.00 |
| 分子式: | C₂₅H₂₂ClFN₆O₂S |
| SMILES: | O=C(NC1=CC=CC(F)=C1)NC2=CC=C(C3=CSC4=C3C(N)=NC=C4C5=CN(CCO)N=C5)C=C2.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ilorasertib hydrochloride (ABT-348 hydrochloride) 是一种有效、ATP 竞争性的多靶点激酶抑制剂，可抑制Aurora C，Aurora B和Aurora A的活性，IC50值分别为 1 nM，7 nM 和 120 nM。Ilorasertib hydrochloride (ABT-348 hydrochloride) 同时抑制RET，PDGFRβ和Flt1的活性，IC50值分别为 7 nM，3 nM 和 32 nM。 |
| IC50和靶点: | [{name:"Aurora C:1 nM (IC50)"},{name: "Aurora B:7 nM (IC50)"},{name: "Aurora B (Y156H):12 nM (IC50)"},{name: "Aurora A:120 nM (IC50)"},{name: "PDGFRα:11 nM (IC50)"},{name: "PDGFRβ:13 nM (IC50)"},{name: "VEGFR1:1 nM (IC50)"},{name: "VEGFR2:2 nM (IC50)"},{name: "VEGFR3:43 nM (IC50)"},{name: "FLT3:1 nM (IC50)"},{name: "CSF-1R:3 nM (IC50)"},{name: "c-KIT:20 nM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
