CGS 15943
Cat. No.：YN420013
CAS No. ：104615-18-1
规格
价格(RMB)
库存
| 产品名称: | CGS 15943 |
| CAS No.: | 104615-18-1 |
| Chemical Name: | 9-chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine |
| Synonyms: | |
| 分子量: | 285.69 |
| 分子式: | C₁₃H₈ClN₅O |
| SMILES: | NC1=NC2=C(C=C(Cl)C=C2)C3=NC(C4=CC=CO4)=NN13 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CGS 15943 是adenosine receptor腺苷受体的非黄嘌呤拮抗剂，具有口服活性。接受人重组 A1，A2A，A2B和 A3 受体转染的 CHO 细胞中，Ki值分别为 3.5、4.2、16 和 50 nM。 |
| IC50和靶点: | [{name:"p110γ:1.1 μM (IC50)"},{name: "p110δ:8.47 μM (IC50)"},{name: "adenosine A1 receptor:3.5 nM (Ki)"},{name: "adenosine A2A receptor:4.2 nM (Ki)"},{name: "adenosine A2B receptor:16 nM (Ki)"},{name: "adenosine A3 receptor:50 nM (Ki)"}] |
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| Solvent & Solubility: |
Klotz, K.-N.Adenosine receptors and their ligandsNaunyn-Schmiedeberg's Arch. Pharmacol.362(4),382-391(2000)
Ghai, G., Francis, J.E., Williams, M., et al.Pharmacological characterization of CGS 15943A: a novel nonxanthine adenosine antagonistJ. Pharmacol. Exp. Ther.242(3),784-790(1987)
Edling, C.E., Selvaggi, F., Ghonaim, R., et al.Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathwayCancer Biol. Ther.15(5),524-532(2014)
Holtzman, S.G.CGS 15943, a nonxanthine adenosine receptor antagonist: effects on locomotor activity of nontolerant and caffeine-tolerant ratsLife Sci.49(21),1563-1570(1991)
Weerts, E.M., and Griffiths, R.R.The adenosine receptor antagonist CGS15943 reinstates cocaine-seeking behavior and maintains self-administration in baboonsPsychopharmacology (Berl)168(1-2),155-163(2003)
