IPI549
Cat. No.：YN420014
CAS No. ：1693758-51-8
规格
价格(RMB)
库存
| 产品名称: | IPI549 |
| CAS No.: | 1693758-51-8 |
| Chemical Name: | 2-amino-N-[(1S)-1-[1,2-dihydro-8-[2-(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-3-isoquinolinyl]ethyl]-pyrazolo[1,5-a]pyrimidine-3-carboxamide |
| Synonyms: | IPI-549 |
| 分子量: | 528.56 |
| 分子式: | C₃₀H₂₄N₈O₂ |
| SMILES: | O=C(C1=C2N=CC=CN2N=C1N)N[C@H](C3=CC4=C(C(N3C5=CC=CC=C5)=O)C(C#CC6=CN(C)N=C6)=CC=C4)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IPI549 是一种有效的选择性PI3Kγ抑制剂，IC50为 16 nM，选择性比其他脂类和蛋白质激酶高出 100 多倍。 |
| IC50和靶点: | [{name:"PI3Kγ:16 nM (IC50)"},{name: "PI3Kα:3.2 μM (IC50)"},{name: "PI3Kβ:3.5 μM (IC50)"}] |
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| Solvent & Solubility: |
Evans, C.A., Liu, T., Lescarbeau, A., et al.Discovery of a selective phosphoinositide-3-kinase (PI3K)-γ inhibitor (IPI-549) as an immuno-oncology clinical candidateACS Med. Chem. Lett.7(9),862-867(2016)
De Vera, A.A., Gupta, P., Lei, Z., et al.Immuno-oncology agent IPI-549 is a modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated multidrug resistance (MDR) in cancer: In vitro and in vivoCancer Lett.442,91-103(2019)
