IC-87114
Cat. No.：YN420017
CAS No. ：371242-69-2
规格
价格(RMB)
库存
| 产品名称: | IC-87114 |
| CAS No.: | 371242-69-2 |
| Chemical Name: | 2-[(6-amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone |
| Synonyms: | IC 87114 |
| 分子量: | 397.43 |
| 分子式: | C₂₂H₁₉N₇O |
| SMILES: | O=C1N(C(CN2C3=C(C(N)=NC=N3)N=C2)=NC4=CC=CC(C)=C14)C5=C(C)C=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IC-87114 是一种有效的选择性PI3Kδ抑制剂，IC50为 0.5 μM。 |
| IC50和靶点: | [{name:"PI3Kδ:0.5 μM (IC50)"},{name: "PI3Kγ:29 μM (IC50)"},{name: "PI3Kβ:75 μM (IC50)"}] |
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| Solvent & Solubility: |
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Saudemont, A., Garçon, F., Yadi, H., et al.p110γ and p110δ isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and diseaseProc. Natl. Acad. Sci. USA106(14),5795-5800(2009)
Niedermeier, M., Hennessy, B.T., Knight, Z.A., et al.Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: A novel therapeutic approachBlood113(22),5549-5557(2009)
Sujobert, P., Bardet, V., Cornillet-Lefebvre, P., et al.Essential role for the p110δ isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemiaBlood106(3),1063-1066(2005)
Lee, K.S., Lee, H.K., Hayflick, J.S., et al.Inhibition of phosphoinositide 3-kinase δ attenuates allergic airway inflammation and hyperresponsiveness in murine asthma modelFASEB J.20(3),455-465(2006)
