TGX-221
Cat. No.：YN420019
CAS No. ：663619-89-4
规格
价格(RMB)
库存
| 产品名称: | TGX-221 |
| CAS No.: | 663619-89-4 |
| Chemical Name: | 7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one |
| Synonyms: | TGX221 |
| 分子量: | 364.44 |
| 分子式: | C₂₁H₂₄N₄O₂ |
| SMILES: | O=C1N2C(C(C(NC3=CC=CC=C3)C)=CC(C)=C2)=NC(N4CCOCC4)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TGX-221 是一种高效的、选择性的、细胞膜渗透的PI3K p110β抑制剂，常用于癌症研究。 |
| IC50和靶点: | [{name:"p110β:8.5 nM (IC50)"},{name: "p110δ:211 nM (IC50)"}] |
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| Solvent & Solubility: |
Rameh, L.E., and Cantley, L.C.The role of phosphoinositide 3-kinase lipid products in cell functionJ. Biol. Chem.274(13),8347-8350(1999)
Vivanco, I., and Sawyers, C.L.The phosphatidylinositol 3-kinase-AKT pathway in human cancerNat. Rev. Cancer2(7),489-501(2002)
Hennessy, B.T., Smith, D.L., Ram, P.T., et al.Exploiting the PI3K/AKT pathway for cancer drug discoveryNat. Rev. Drug Discov.4(12),988-1004(2005)
Jackson, S.P., Schoenwaelder, S.M., Goncalves, I., et al.PI 3-kinase p110ß: A new target for antithrombotic therapyNat. Med.11(5),507-514(2005)
