GDC-0326
Cat. No.：YN420023
CAS No. ：1282514-88-8
规格
价格(RMB)
库存
| 产品名称: | GDC-0326 |
| CAS No.: | 1282514-88-8 |
| Chemical Name: | (2S)-2-[[5,6-dihydro-2-[1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]oxy]-propanamide |
| Synonyms: | GDC 0326,GDC0326 |
| 分子量: | 382.42 |
| 分子式: | C₁₉H₂₂N₆O₃ |
| SMILES: | C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GDC-0326是有效，选择性的PI3Kα抑制剂，Ki值为0.2 nM。 |
| IC50和靶点: | [{name:"PI3Kα:0.2 nM (Ki)"},{name: "PI3Kβ:26.6 nM (Ki)"},{name: "PI3Kδ:4 nM (Ki)"},{name: "PI3Kγ:10.2 nM (Ki)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Heffron, T.P., Heald, R.A., Ndubako, C.O., et al.The rational design of selective benzoxazepin inhibitors of the α-isoform of phosphoinositide 3-kinase culminating in the identification of (S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)J. Med. Chem.59(3),985-1002(2016)
Soler, A., Figueiredo, A.M., Castel, P., et al.Therapeutic benefit of selective inhibition of p110α PI3-kinase in pancreatic neuroendocrine tumorsClin. Cancer Res.22(23),5805-5817(2016)
