PIK-294
Cat. No.：YN420037
CAS No. ：900185-02-6
规格
价格(RMB)
库存
| 产品名称: | PIK-294 |
| CAS No.: | 900185-02-6 |
| Chemical Name: | 2-[[4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone |
| Synonyms: | PIK294 |
| 分子量: | 489.53 |
| 分子式: | C₂₈H₂₃N₇O₂ |
| SMILES: | O=C1N(C2=CC=CC=C2C)C(CN3N=C(C(C3=NC=N4)=C4N)C5=CC(O)=CC=C5)=NC6=CC=CC(C)=C16 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PIK-294 是一种有效的选择性p110δ抑制剂，IC50为 10 nM。 |
| IC50和靶点: | [{name:"p110δ:10 nM (IC50)"},{name: "p110γ:160 nM (IC50)"},{name: "p110β:490 nM (IC50)"},{name: "p110α:10 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Knight, Z.A., Gonzalez, B., Feldman, M.E., et al.A pharmacological map of the PI3-K family defines a role for p110α in insulin signalingCell125(4),733-747(2006)
Apsel, B., Blair, J.A., Gonzalez, B., et al.Targeted polypharmacology: Discovery of dual inhibitors of tyrosine and phosphoinositide kinasesNat. Chem. Biol.4(11),691-699(2008)
Martin, K.J.S., Muessel, M.J., Pullar, C.E., et al.The role of phosphoinositide 3-kinases in neutrophil migration in 3D collagen gelsPLoS One10(2),e0116250(2015)
