PIK-93
Cat. No.：YN420107
CAS No. ：593960-11-3
规格
价格(RMB)
库存
| 产品名称: | PIK-93 |
| CAS No.: | 593960-11-3 |
| Chemical Name: | N-[5-[4-chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]-acetamide |
| Synonyms: | PIK 93 |
| 分子量: | 389.88 |
| 分子式: | C₁₄H₁₆ClN₃O₄S₂ |
| SMILES: | CC(NC1=NC(C)=C(S1)C2=CC=C(C(S(=O)(NCCO)=O)=C2)Cl)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PIK-93 是一种合成的，有效的PI4KIIIβ抑制剂，IC50值为 19 nM，同时可抑制PI3Kγ和PI3Kα的活性，IC50值分别为 16 nM 和 39 nM。 |
| IC50和靶点: | [{name:"PI4KIIIβ:19 nM (IC50)"},{name: "PI4KIIIα:1.1 μM (IC50)"},{name: "p110γ:16 nM (IC50)"},{name: "p110α:39 nM (IC50)"},{name: "p110δ:120 nM (IC50)"},{name: "p110β:590 nM (IC50)"},{name: "PI3KC2β:140 nM (IC50)"},{name: "PI3KC2α:16 μM (IC50)"},{name: "hsVPS34:320 nM (IC50)"},{name: "DNA-PK:64 nM (IC50)"},{name: "ATM:490 nM (IC50)"},{name: "mTORC1:1.38 μM (IC50)"},{name: "ATR:17 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Knight, Z.A., Gonzalez, B., Feldman, M.E., et al.A pharmacological map of the PI3-K family defines a role for p110α in insulin signalingCell125(4),733-747(2006)
Hsu, N.Y., Ilnytska, O., Belov, G., et al.Viral reorganization of the secretory pathway generates distinct organelles for RNA replicationCell141(5),799-811(2010)
Toth, B., Balla, A., Ma, H., et al.Phosphatidylinositol 4-kinase IIIβ regulates the transport of ceramide between the endoplasmic reticulum and GolgiJ. Biol. Chem.281(47),36369-36377(2006)
