PI-3065
Cat. No.：YN420112
CAS No. ：955977-50-1
规格
价格(RMB)
库存
| 产品名称: | PI-3065 |
| CAS No.: | 955977-50-1 |
| Chemical Name: | 6-[[4-(cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine |
| Synonyms: | PI3065 |
| 分子量: | 506.64 |
| 分子式: | C₂₇H₃₁FN₆OS |
| SMILES: | FC(C=CC1=C2C=CN1)=C2C3=NC4=C(SC(CN5CCN(CC6CC6)CC5)=C4)C(N7CCOCC7)=N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PI-3065 是一种有效的PI3K p110δ抑制剂，IC50和Ki值分别为 5 nM 和 1.5 nM；对 p110α，p110β，p110γ 的作用较弱，IC50分别为 910，600，>10000 nM。 |
| IC50和靶点: | [{name:"p110α:910 nM (IC50)"},{name: "p110β:600 nM (IC50)"},{name: "p110δ:5 nM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Ali, K., Soond, D.R., Pineiro, R., et al.Inactivation of PI3K p110δ breaks regulatory T-cell-mediated immune tolerance to cancerNature510(7505),407-411(2014)
