Umbralisib hydrochloride
Cat. No.：YN420115
CAS No. ：1532533-78-0
规格
价格(RMB)
库存
| 产品名称: | Umbralisib hydrochloride |
| CAS No.: | 1532533-78-0 |
| Chemical Name: | 2-[(1S)-1-[4-Amino-3-[3-fluoro-4-(1-methylethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)-4H-1-benzopyran-4-one Hydrochloride |
| Synonyms: | TGR-1202 hydrochloride; RP5264 hydrochloride |
| 分子量: | 608.01 |
| 分子式: | C₃₁H₂₅ClF₃N₅O₃ |
| SMILES: | #116Ybr5kUkt8bhz8Nkz8NktCi9z8bhpZUktvN+x8Jmn3J4bYyr53JkNZU+5ZUkt YNkt8ag53UktCi9z8b8p8bUz8am/3U4z8N4z8bUb3UkpYNk7ZU+5ZUktCig5ZUkA +i0MXsr5Mx== |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Umbralisib hydrochloride (TGR-1202 hydrochloride) 是一种新颖的PI3Kδ抑制剂，IC50和EC50值分别为 22.2 nM 和 24.3 nM；Umbralisib hydrochloride (TGR-1202 hydrochloride) 同时可抑制CK1ε，EC50值为 6.0 μM。 |
| IC50和靶点: | [{name:"PI3Kδ:22.2 nM (EC50)"},{name: "PI3Kδ:6.2 nM (Kd)"},{name: "PI3Kγ:1400 nM (Kd)"},{name: "PI3Kβ:>10000 nM (Kd)"},{name: "PI3Kα:>10000 nM (Kd)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Vakkalanka, S. K. V. S., et al., PCT Int. Appl., 57pp., (2014)
