Serabelisib
Cat. No.：YN420116
CAS No. ：1268454-23-4
规格
价格(RMB)
库存
| 产品名称: | Serabelisib |
| CAS No.: | 1268454-23-4 |
| Chemical Name: | [6-(2-amino-5-benzoxazolyl)imidazo[1,2-a]pyridin-3-yl]-4-morpholinyl-methanone |
| Synonyms: | MLN1117; INK1117; TAK-117 |
| 分子量: | 363.37 |
| 分子式: | C₁₉H₁₇N₅O₃ |
| SMILES: | O=C(C1=CN=C2C=CC(C3=CC=C(OC(N)=N4)C4=C3)=CN21)N5CCOCC5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Serabelisib (MLN1117) 是一种选择性的p110α抑制剂,IC50值为 15 nM。 |
| IC50和靶点: | [{name:"p110α:15 nM (IC50)"},{name: "p110β:4500 nM (IC50)"},{name: "p110δ:13900 nM (IC50)"},{name: "p110γ:1900 nM (IC50)"},{name: "mTOR:1670 nM (IC50)"}] |
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| Solvent & Solubility: |
So, L., Yea, S.S., Oak, J.S., et al.Selective inhibition of phosphoinositide 3-kinase p110α preserves lymphocyte functionJ. Biol. Chem.288(8),5718-5731(2013)
Yea, S.S., So, L., Mallya, S., et al.Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell functionPLoS One9(6),(2014)
