SAR405
Cat. No.：YN420130
CAS No. ：1523406-39-4
规格
价格(RMB)
库存
| 产品名称: | SAR405 |
| CAS No.: | 1523406-39-4 |
| Chemical Name: | (8S)-9-[(5-chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one |
| Synonyms: | SAR-405;SAR 405 |
| 分子量: | 443.85 |
| 分子式: | C₁₉H₂₁ClF₃N₅O₂ |
| SMILES: | O=C1N(C2=NC(N3[C@H](C)COCC3)=C1)CC[C@@H](C(F)(F)F)N2CC4=CC(Cl)=CN=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SAR405 是首创的，选择性的，具有ATP竞争性的 PI3K III (PIK3C3) 亚型Vps34抑制剂 (IC50=1.2 nM;Kd=1.5 nM)。SAR405 抑制饥饿或 mTOR 抑制诱导的自噬。具有抗癌活性。 |
| IC50和靶点: | [{name:"Vps34:1.2 nM (IC50)"},{name: "Vps34:1.5 nM (Kd)'}, 'Autophagy'] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ronan, B., Flamand, O., Vescovi, L., et al.A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagyNat. Chem. Biol.,(2014)
