Vps34-PIK-III
Cat. No.：YN420137
CAS No. ：1383716-40-2
规格
价格(RMB)
库存
| 产品名称: | Vps34-PIK-III |
| CAS No.: | 1383716-40-2 |
| Chemical Name: | 4'-(cyclopropylmethyl)-N2-4-pyridinyl-[4,5'-bipyrimidine]-2,2'-diamine |
| Synonyms: | VPS34-IN2 |
| 分子量: | 319.36 |
| 分子式: | C₁₇H₁₇N₇ |
| SMILES: | NC1=NC=C(C2=CC=NC(NC3=CC=NC=C3)=N2)C(CC4CC4)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Vps34-PIK-III是有效选择性的VPS34抑制剂，IC50值为18 nM。 |
| IC50和靶点: | [{name:"Vps34:18 nM (IC50)"},{name: "PI(3)Kδ:1.2 μM (IC50)"},{name: "PI(3)Kγ:3.04 μM (IC50)"},{name: "PI(3)Kα:3.96 μM (IC50)"}] |
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| Solvent & Solubility: |
Dowdle, W.E., Nyfeler, B., Nagel, J., et al.Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivoNat. Cell Biol.16(11),1069-1079(2014)
