A66
Cat. No.：YN420157
CAS No. ：1166227-08-2
规格
价格(RMB)
库存
| 产品名称: | A66 |
| CAS No.: | 1166227-08-2 |
| Chemical Name: | (2S)-N1-[2-(1,1-dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide |
| Synonyms: | A66;(2S)-1-N-[5-(2-tert-Butyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide;(2S)-N1-[2-(tert-Butyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide;(S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-[(2-tert-butyl-4' |
| 分子量: | 393.53 |
| 分子式: | C₁₇H₂₃N₅O₂S₂ |
| SMILES: | CC(C)(C1=NC(C2=C(N=C(S2)NC(N3[C@@H](CCC3)C(N)=O)=O)C)=CS1)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A66 是一种高特异性的选择性的p110α抑制剂，IC50为 32 nM。 |
| IC50和靶点: | [{name:"p110α:32 nM (IC50)"},{name: "p110α E545K:30 nM (IC50)"},{name: "p110α H1047R:43 nM (IC50)"},{name: "p110γ:3480 nM (IC50)"},{name: "PI3K-C2β:462 nM (IC50)"},{name: "PI4Kβ:236 nM (IC50)"}] |
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| Solvent & Solubility: |
Jamieson, S., Flanagan, J.U., Kolekar, S., et al.A drug targeting only p110a can block phosphoinositide 3-kinase signalling and tumour growth in certain cell typesBiochem. J.438(1),53-62(2011)
Smith, G.C., Ong, W.K., Rewcastle, G.W., et al.Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivoBiochem. J.442(1),161-169(2012)
So, L., Yea, S.S., Oak, J.S., et al.Selective inhibition of phosphoinositide 3-kinase p110α preserves lymphocyte functionJ. Biol. Chem.288(8),5718-5731(2013)
