AMG 511
Cat. No.：YN420166
CAS No. ：1253573-53-3
规格
价格(RMB)
库存
| 产品名称: | AMG 511 |
| CAS No.: | 1253573-53-3 |
| Chemical Name: | 4-[2-[(5-Fluoro-6-methoxy-3-pyridinyl)amino]-5-[(1R)-1-[4-(methylsulfonyl)-1-piperazinyl]ethyl]-3-pyridinyl]-6-methyl-1,3,5-Triazin-2-amine |
| Synonyms: | |
| 分子量: | 517.58 |
| 分子式: | C₂₂H₂₈FN₉O₃S |
| SMILES: | NC1=NC(C2=CC([C@H](N3CCN(S(=O)(C)=O)CC3)C)=CN=C2NC4=CC(F)=C(OC)N=C4)=NC(C)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AMG 511 是一个高效、口服有效的 I 类pan-PI3K抑制剂,对 PI3Kα, β, δ 和 γ 作用的Ki值分别为 4 nM, 6 nM, 2 nM 和 1 nM。AMG 511 减少 p-Akt (Ser473), 体现了它显著抑制了 PI3K 信号。AMG 511 在小鼠胶质母细胞瘤移植瘤模型中具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"PI3Kα:4 nM (Ki)"},{name: "PI3Kβ:6 nM (Ki)"},{name: "PI3Kδ:2 nM (Ki)"},{name: "PI3Kγ:1 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Norman, M. et al.: J. Med. Chem., 55, 7796 (2012)
