GSK2636771
Cat. No.：YN420203
CAS No. ：1372540-25-4
规格
价格(RMB)
库存
| 产品名称: | GSK2636771 |
| CAS No.: | 1372540-25-4 |
| Chemical Name: | 2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid |
| Synonyms: | GSK 2636771,GSK-2636771 |
| 分子量: | 433.42 |
| 分子式: | C₂₂H₂₂F₃N₃O₃ |
| SMILES: | CC1=NC2=C(C(O)=O)C=C(C=C2N1CC3=CC=CC(C(F)(F)F)=C3C)N4CCOCC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK2636771 是一种口服有效的选择性PI3Kβ抑制剂，Ki和IC50分别为0.89，5.2 nM，比p110α和p110γ的选择性高900倍，比p110δ同种型的选择性高10倍。 |
| IC50和靶点: | [{name:"PI3Kβ:0.89 nM (Ki)"},{name: "PI3Kβ:5.2 nM (IC50)"}] |
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| Solvent & Solubility: |
Rivero, R.A., and Hardwicke, M.A.Abstract 2913: Identification of GSK263771, a potent and selective, orally bioavailable inhibitor of the phosphatidylinositol 3-kinaseβ(PI3Kα) for the treatment of PTEN deficient tumorsCancer Res.72,2913-2913(2012)
Weigelt, B., Warne, P.H., Lambros, M.B., et al.PI3K pathway dependencies in endometrioid endometrial cancer cell linesClin. Cancer Res.19(13),3533-3544(2013)
