CZC24832
Cat. No.：YN420208
CAS No. ：1159824-67-5
规格
价格(RMB)
库存
| 产品名称: | CZC24832 |
| CAS No.: | 1159824-67-5 |
| Chemical Name: | 5-(2-amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1,1-dimethylethyl)-3-pyridinesulfonamide |
| Synonyms: | |
| 分子量: | 364.40 |
| 分子式: | C₁₅H₁₇FN₆O₂S |
| SMILES: | FC1=CC(C2=CC(S(=O)(NC(C)(C)C)=O)=CN=C2)=CN3C1=NC(N)=N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CZC24832 是一种有效的选择性PI3Kγ抑制剂，IC50为 27 nM，表观解离常数(Kdapp) 为 19 nM。 |
| IC50和靶点: | [{name:"PI3Kβ:1.1 μM (IC50)"},{name: "PI3Kδ:8.194 μM (IC50)"},{name: "PI3Kγ:27 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Bell, K., Sunose, M., Ellard, K., et al.SAR studies around a series of triazolopyridines as potent and selective PI3Kγ inhibitorsBioorg. Med. Chem. Lett.22(16),5257-5263(2012)
Bergamini, G., Bell, K., Shimamura, S., et al.A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiationNat. Chem. Biol.8(6),(2012)
