Pilaralisib
Cat. No.：YN420240
CAS No. ：934526-89-3
规格
价格(RMB)
库存
| 产品名称: | Pilaralisib |
| CAS No.: | 934526-89-3 |
| Chemical Name: | 2-amino-N-[3-[[[3-[(2-chloro-5-methoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-2-methyl-propanamide |
| Synonyms: | XL-147; SAR245408 |
| 分子量: | 541.02 |
| 分子式: | C₂₅H₂₅ClN₆O₄S |
| SMILES: | CC(C)(N)C(NC1=CC=CC(S(=O)(NC2=NC3=CC=CC=C3N=C2NC4=CC(OC)=CC=C4Cl)=O)=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pilaralisib (XL147; SAR245408) 是一种有效的选择性 I 类PI3Ks 抑制剂，抑制 PI3Kα，PI3Kβ，PI3Kγ 和 PI3Kδ，IC50分别为 39 nM，383 nM，23 nM 和 36 nM。 |
| IC50和靶点: | [{name:"PI3Kα:39 nM (IC50)"},{name: "PI3Kβ:383 nM (IC50)"},{name: "PI3Kδ:36 nM (IC50)"},{name: "PI3Kγ:23 nM (IC50)"},{name: "Vps34:6974 nM (IC50)"},{name: "DNA-PK:4750 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Foster, P., Yamaguchi, K., Hsu, P.P., et al.The selective PI3K inhibitor XL147 (SAR245408) inhibits tumor growth and survival and potentiates the activity of chemotherapeutic agents in preclinical tumor modelsMol. Cancer Ther.14(4),931-940(2015)
Chakrabarty, A., Sánchez, V., Kuba, M.G., et al.Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitorsProc. Natl. Acad. Sci. USA109(8),2718-2723(2012)
