CNX-1351
Cat. No.：YN420242
CAS No. ：1276105-89-5
规格
价格(RMB)
库存
| 产品名称: | CNX-1351 |
| CAS No.: | 1276105-89-5 |
| Chemical Name: | 1-[4-[[2-(1H-indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione |
| Synonyms: | 1-[4-[[2-(1H-吲唑-4-基)-4-(4-吗啉基)噻吩并[3,2-D]嘧啶-6-基]甲基]-1-哌嗪基]-6-甲基-5-庚烯-1,4-二酮 |
| 分子量: | 573.71 |
| 分子式: | C₃₀H₃₅N₇O₃S |
| SMILES: | C/C(C)=C/C(CCC(N1CCN(CC2=CC3=NC(C4=CC=CC5=C4C=NN5)=NC(N6CCOCC6)=C3S2)CC1)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CNX-1351 是一种有效的选择性PI3Kα抑制剂，IC50为 6.8 nM。 |
| IC50和靶点: | [{name:"PI3Kα:6.8 nM (IC50)"},{name: "PI3Kβ:166 nM (IC50)"},{name: "PI3Kδ:240.3 nM (IC50)"},{name: "PI3Kγ:3020 nM (IC50)"}] |
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| Solvent & Solubility: |
Nacht, M., Qiao, L., Sheets, M.P., et al.Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3KαJ. Med. Chem.56(3),712-721(2013)
