Duvelisib
Cat. No.：YN420249
CAS No. ：1201438-56-3
规格
价格(RMB)
库存
| 产品名称: | Duvelisib |
| CAS No.: | 1201438-56-3 |
| Chemical Name: | 8-chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-1(2H)-isoquinolinone |
| Synonyms: | IPI-145; INK1197 |
| 分子量: | 416.86 |
| 分子式: | C₂₂H₁₇ClN₆O |
| SMILES: | O=C1N(C2=CC=CC=C2)C([C@@H](NC3=C4N=CNC4=NC=N3)C)=CC5=C1C(Cl)=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Duvelisib 是一种选择性p100δ抑制剂，作用于 p110δ, p110γ, p110β 和 p110α，IC50分别为 2.5 nM，27.4 nM，85 nM 和 1602 nM。 |
| IC50和靶点: | [{name:"p110δ:2.5 nM (IC50)"},{name: "p110γ:27.4 nM (IC50)"},{name: "p110β:85 nM (IC50)"},{name: "p110α:1602 nM (IC50)"}] |
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Winkler, D.G., Faia, K.L., DiNitto, J.P., et al.PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease modelsChem. Biol.20(11),1364-1374(2013)
Boyle, D.L., Kim, H.R., Topolewski, K., et al.Novel phosphoinositide 3-kinase δ,γ inhibitor: Potent anti-inflammatory effects and joint protection in models of rheumatoid arthritisJ. Pharmacol. Exp. Ther.348(2),271-280(2014)
Mockler, M.B., Conroy, M.J., and Lysaght, J.Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironmentFront. Oncol.4(107),1-11(2014)
Falasca, M., and Maffucci, T.Targeting p100γ in gastrointestinal cancers: Attack on multiple frontsFront. Physiol.5(391),1-10(2014)
