ZSTK474
Cat. No.：YN420275
CAS No. ：475110-96-4
规格
价格(RMB)
库存
| 产品名称: | ZSTK474 |
| CAS No.: | 475110-96-4 |
| Chemical Name: | 2-(difluoromethyl)-1-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-1H-benzimidazole |
| Synonyms: | ZSTK-474 |
| 分子量: | 417.41 |
| 分子式: | C₁₉H₂₁F₂N₇O₂ |
| SMILES: | FC(C1=NC2=C(N1C3=NC(N4CCOCC4)=NC(N5CCOCC5)=N3)C=CC=C2)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ZSTK474 是一种 ATP 竞争性的泛 I 类PI3K抑制剂，抑制 P13Kα，PI3Kβ，PI3Kδ 和 PI3Kγ，IC50分别为 16 nM，44 nM，4.6 nM 和 49 nM。 |
| IC50和靶点: | [{name:"PI3Kδ:4.6 nM (IC50)"},{name: "PI3Kα:16 nM (IC50)"},{name: "PI3Kβ:44 nM (IC50)"},{name: "PI3Kγ:49 nM (IC50)'}, 'Autophagy'] |
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| Solvent & Solubility: |
Yaguchi, S.i., Fukui, Y., Koshimizu, I., et al.Antitumor activity of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitorJ. Natl. Cancer Inst.98(8),545-556(2006)
Lin, L., Gaut, D., Hu, K., et al.Dual targeting of glioblastoma multiforme with a proteasome inhibitor (Velcade) and a phosphatidylinositol 3-kinase inhibitor (ZSTK474)Int. J. Oncol.44,557-562(2014)
Bertazza, L., Barollo, S., Radu, C.M., et al.Synergistic antitumour activity of RAF265 and ZSTK474 on human TT medullary thyroid cancer cellsJ. Cell. Mol. Med.19(9),2244-2252(2015)
