Euscaphic acid
Cat. No.：YN420308
CAS No. ：53155-25-2
规格
价格(RMB)
库存
| 产品名称: | Euscaphic acid |
| CAS No.: | 53155-25-2 |
| Chemical Name: | 2α,3α,19-trihydroxy-urs-12-en-28-oic acid |
| Synonyms: | 野鸦椿酸 |
| 分子量: | 488.70 |
| 分子式: | C₃₀H₄₈O₅ |
| SMILES: | OC([C@]12[C@]([C@](O)([C@H](C)CC2)C)([H])C3=CC[C@@]([C@@]4([C@@](C(C)([C@H](O)[C@H](O)C4)C)([H])CC5)C)([H])[C@]5(C)[C@]3(C)CC1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Euscaphic acid 是源于R. alceaefolius Poir的三萜，DNA polymerase抑制剂。Euscaphic acid 抑制小牛 DNA 聚合酶 α (pol α) 和大鼠 DNA 聚合酶 β (pol β) 的IC50值分别为 61 和 108 μM。Euscaphic acid 诱导细胞凋亡 (apoptosis)。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Dai, W., Dong, P., Liu, J., et al.Euscaphic acid inhibits proliferation and promotes apoptosis of nasopharyngeal carcinoma cells by silencing the PI3K/AKT/mTOR signaling pathwayAm. J. Transl. Res.11(4),2090-2098(2019)
Ado, M.A., Maulidiani, M., Ismail, I.S., et al.Acetylcholinesterase and α-glucosidase inhibitory compounds from Callicarpa maingayiNat. Prod. Res.35(17),2992-2996(2021)
Kim, I.-T., Ryu, S., Shin, J.-S., et al.Euscaphic acid isolated from roots of Rosa rugosa inhibits LPS-induced inflammatory responses via TLR4-mediated NF-κB inactivation in RAW 264.7 macrophagesJ. Cell. Biochem.113(6),1936-1946(2012)
Jeong, N.-H., Lee, S., Choi, Y.-A., et al.Inhibitory effects of euscaphic acid in the atopic dermatitis model by reducing skin inflammation and intense pruritusInflammation45(4),1680-1691(2022)
