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740 Y-P

Cat. No.:YN420320

  • CAS No. :1236188-16-1

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    • 产品名称: 740 Y-P
      CAS No.: 1236188-16-1
      Chemical Name: L-arginyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-tryptophyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginyl-L-methionyl-L-lysyl-L-tryptophyl-L-lysyl-L-lysyl-L-seryl-L-α-aspartylglycylglycyl-O-phosphono-L-tyrosyl-L-methionyl-L-α-aspar
      Synonyms:740YPDGFR; PDGFR 740Y-P
      分子量:3270.70
      分子式:C₁₄₁H₂₂₂N₄₃O₃₉PS₃
      SMILES:[RQIKIWFQNRRMKWKKSDGG-{PO2-Tyr}-MDMS]
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: 740 Y-P (740YPDGFR; PDGFR 740Y-P) 是一个有效的,具有细胞渗透性的PI3K激活剂。740 Y-P 很容易结合含有 p85 的 N- 和 C- 末端 SH2 结构域的 GST 融合蛋白,但不能单独结合 GST。
      IC50和靶点:
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    • Derossi, D., Williams, E.J., Green, P.J., et al.Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptideBiochem. Biophys. Res. Commun.251(1),148-152(1998)

      Qin, B., Zeng, Z., Xu, J., et al.Emodin inhibits invasion and migration of hepatocellular carcinoma cells via regulating autophagy-mediated degradation of snail and β-cateninBMC Cancer22(1),671(2022)

      Turovsky, E.A., Turovskaya, M.V., Gaidin, S.G., et al.Cytokine IL-10, activators of PI3-kinase, agonists of α-2 adrenoreceptor and antioxidants prevent ischemia-induced cell death in rat hippocampal culturesArch. Biochem. Biophys.615,35-43(2017)

      Sakurai, M., Ishitsuka, K., Ito, R., et al.Chemically defined cytokine-free expansion of human haematopoietic stem cellsNature615(7950),127-133(2023)

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