KDU691
Cat. No.：YN420143
CAS No. ：1513879-19-0
规格
价格(RMB)
库存
| 产品名称: | KDU691 |
| CAS No.: | 1513879-19-0 |
| Chemical Name: | N-(4-chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]-imidazo[1,2-a]pyrazine-6-carboxamide |
| Synonyms: | KDU691 |
| 分子量: | 419.86 |
| 分子式: | C₂₂H₁₈ClN₅O₂ |
| SMILES: | ClC1=CC=C(N(C(C2=CN3C(C=N2)=NC=C3C4=CC=C(C(NC)=O)C=C4)=O)C)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KDU691 是一种咪唑吡嗪类药物，对血阶段的裂殖体、配子体和肝期具有较强的抗寄生虫活性，KDU691 是一种PlasmodiumPI4K抑制剂。KDU691 选择性抑制双氢青蒿素预处理的恶性疟原虫。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
McNamara, C.W., Lee, M.C., Lim, C.S., et al.Targeting Plasmodium phosphatidylinositol 4-kinase to eliminate malariaNature504(7479),248-253(2013)
Zou, B., Nagle, A., Chatterjee, A.K., et al.Lead optimization of imidazopyrazines: a new class of antimalarial with activity on Plasmodium liver stagesACS Med. Chem. Lett.5(8),947-950(2014)
Zeeman, A.M., Lakshminarayana, S.B., van der Werff, N., et al.PI4 kinase is a prophylactic but not radical curative target in Plasmodium vivax-type malaria parasitesAntimicrob. Agents Chemother.60(5),2858-2863(2016)
