Vacuolin-1
Cat. No.：YN420098
CAS No. ：351986-85-1
规格
价格(RMB)
库存
| 产品名称: | Vacuolin-1 |
| CAS No.: | 351986-85-1 |
| Chemical Name: | 3-iodo-benzaldehyde,2-[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone |
| Synonyms: | Vacuolin 1;Vacuolin1 |
| 分子量: | 577.42 |
| 分子式: | C₂₆H₂₄IN₇O |
| SMILES: | IC1=CC(/C=N/NC2=NC(N(C3=CC=CC=C3)C4=CC=CC=C4)=NC(N5CCOCC5)=N2)=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Vacuolin-1 是一种有效的细胞渗透溶酶体胞吐 (lysosomal exocytosis) 抑制剂。Vacuolin-1 阻断了溶酶体 Ca2+依赖性的胞吐作用，在不影响再封闭过程的情况下阻止溶酶体内容物的释放。Vacuolin-1 是一种有效的选择性PIKfyve抑制剂，通过损害溶酶体成熟来抑制晚期自噬 (autophagy)。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Cerny, J., Feng, Y., Yu, A., et al.The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealingEMBO Rep.5(9),883-888(2004)
