Rp-cAMPS triethylammonium salt
Cat. No.：YN440018
CAS No. ：151837-09-1
规格
价格(RMB)
库存
| 产品名称: | Rp-cAMPS triethylammonium salt |
| CAS No.: | 151837-09-1 |
| Chemical Name: | cyclic 3',5'-[hydrogen (R)-phosphorothioate] adenosine, triethylammonium salt |
| Synonyms: | |
| 分子量: | 446.46 |
| 分子式: | C₁₆H₂₇N₆O₅PS |
| SMILES: | O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])O[P@@](OC2)(S)=O)N3C4=C(C(N)=NC=N4)N=C3.CCN(CC)CC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rp-cAMPS triethylammonium salt，一种 cAMP 的类似物，是一种 cAMP 诱导的PKA I和PKA II活化 (Ki分别为 12.5 µM 和 4.5 µM) 的有效的，竞争性拮抗剂。Rp-cAMPS triethylammonium salt 耐磷酸二酯酶水解。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Schaap, P., van Ments-Cohen, M., Soede, R.D., et al.Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in DictyosteliumJ. Biol. Chem.268(9),6323-6331(1993)
De Wit, R.J.W., Hekstra, D., Jastorff, B., et al.Inhibitory action of certain cyclophosphate derivatives of cAMP on cAMP-dependent protein kinasesEur. J. Biochem.142(2),255-260(1984)
Van Haastert, P.J.M., van Driel, R., Jastorff, B., et al.Competitive cAMP antagonists for cAMP-receptor proteinsJ. Biol. Chem.259(16),10020-10024(1984)
Jarvest, R.L., Lowe, G., Baraniak, J., et al.A stereochemical investigation of the hydrolysis of cyclic AMP and the (Sp)-and (Rp)-diastereoisomers of adenosine cyclic 3':5'-phosphorothioate by bovine heart and baker's-yeast cyclic AMP phosphodiesterasesBiochem. J.203(2),461-470(1982)
Schwede, F., Maronde, F., Genieser, H., et al.Cyclic nucleotide analogs as biochemical tools and prospective drugsPharmacol. Ther.87(2),199-226(2000)
Yokozaki, H., Tortora, G., Pepe, S., et al.Unhydrolyzable analogues of adenosine 3':5'-monophosphate demonstrating growth inhibition and differentiation in human cancer cellsCancer Res.52(9),2504-2508(1992)
