Rp-8-CPT-cAMPS sodium
Cat. No.：YN440195
CAS No. ：221905-35-7
规格
价格(RMB)
库存
| 产品名称: | Rp-8-CPT-cAMPS sodium |
| CAS No.: | 221905-35-7 |
| Chemical Name: | 8-[(4-chlorophenyl)thio]-adenosine cyclic 3',5'-[hydrogen (R)-phosphorothioate], monosodium salt |
| Synonyms: | |
| 分子量: | 509.86 |
| 分子式: | C₁₆H₁₄ClN₅NaO₅PS₂ |
| SMILES: | O[C@H]1[C@](O[C@@](CO2)([H])[C@@]1([H])O[P@@]2([S-])=O)([H])N3C4=NC=NC(N)=C4N=C3SC(C=C5)=CC=C5Cl.[Na+] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rp-8-CPT-cAMPS sodium，一种 cAMP 类似物，是 cAMP 诱导的依赖 cAMP 的PKA I和PKA II活化的有效和竞争性的拮抗剂。Rp-8-CPT-cAMPS sodium 优先选择 RI 的位点 A 与 RII 的位点 B。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Schwede, F., Maronde, F., Genieser, H., et al.Cyclic nucleotide analogs as biochemical tools and prospective drugsPharmacol. Ther.87(2),199-226(2000)
Dostmann, W.R., Taylor, S.S., Genieser, H.G., et al.Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioatesJ. Biol. Chem.265(18),10484-10491(1990)
Gjertsen, B.T., Mellgran, G., Otten, A., et al.Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1β actionJ. Biol. Chem.270(35),20599-20607(1995)
