CCG215022
Cat. No.：YN440388
CAS No. ：1813527-81-9
规格
价格(RMB)
库存
| 产品名称: | CCG215022 |
| CAS No.: | 1813527-81-9 |
| Chemical Name: | 4-[4-fluoro-3-[[(2-pyridinylmethyl)amino]carbonyl]phenyl]-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo-5-pyrimidinecarboxamide |
| Synonyms: | CCG215022,CCG-215022,CCG 215022 |
| 分子量: | 499.50 |
| 分子式: | C₂₆H₂₂FN₇O₃ |
| SMILES: | CC(N1)=C(C(NC2=CC=C(NN=C3)C3=C2)=O)C(C4=CC(C(NCC5=CC=CC=N5)=O)=C(F)C=C4)NC1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CCG215022 是一种G蛋白偶联受体激酶 (GRK) 抑制剂，作用于GRK2，GRK5和GRK1，IC50分别为 0.15±0.07 μM，0.38±0.06 μM 和 3.9±1 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Homan, K.T., Waldschmidt, H.V., Glukhova, A., et al.Crystal structure of G protein-coupled receptor kinase 5 in complex with a rationally designed inhibitorJ. Biol. Chem.290(34),20649-20659(2015)
Rainbow, R.D., Brennan, S., Jackson, R., et al.Small-molecule G protein-coupled receptor kinase inhibitors attenuate G protein-coupled receptor kinase 2-mediated desensitization of vasoconstrictor-induced arterial contractionsMol. Pharmacol.94(3),1079-1091(2018)
