LXS196
Cat. No.：YN310048
CAS No. ：1874276-76-2
| 产品名称: | LXS196 |
| CAS No.: | 1874276-76-2 |
| Chemical Name: | 3-amino-N-[3-(4-amino-4-methyl-1-piperidinyl)-2-pyridinyl]-6-[3-(trifluoromethyl)-2-pyridinyl]-2-pyrazinecarboxamide |
| Synonyms: | IDE-196 |
| 分子量: | 472.47 |
| 分子式: | C₂₂H₂₃F₃N₈O |
| SMILES: | NC1=C(C(NC2=C(N3CCC(C)(N)CC3)C=CC=N2)=O)N=C(C4=NC=CC=C4C(F)(F)F)C=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LXS196 是有效的、选择性的和具有口服活性的蛋白激酶C (PKC) 抑制剂，对PKCα、PKCθ 和 GSK3β 的 IC50值分别为 1.9 nM、0.4 nM 和 3.1 μM。有潜力用于葡萄膜黑素瘤的研究。 |
| IC50和靶点: | [{name:"PKCα:1.9 nM (IC50)"},{name: "PKCθ:0.4 nM (IC50)"},{name: "GSK3β:3.1 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Luzzio, M.J., Papillon, J., and Visser, M.S.Protein kinase C inhibitors and methods of their use,(2016)
