Go6976
Cat. No.：YN310050
| 产品名称: | Go6976 |
| CAS No.: | 136194-77-9 |
| Chemical Name: | 5,6,7,13-tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile |
| Synonyms: | PD406976 |
| 分子量: | 378.43 |
| 分子式: | C₂₄H₁₈N₄O |
| SMILES: | N#CCCN(C1=C2C(CNC3=O)=C3C4=C1N(C)C5=C4C=CC=C5)C6=C2C=CC=C6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Go6976 是蛋白激酶C (PKC) 的一个抑制剂，其IC50值为20 nM。 |
| IC50和靶点: | |
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Martiny-Baron, G., Kazanietz, M.G., Mischak, H., et al.Selective inhibition of protein kinase C isoenzymes by the indolocarbazole Gö 6976J. Biol. Chem.268,9194-9197(1993)
Kohn, E.A., Yoo, C.J., and Eastman, A.The protein kinase C inhibitor Gö6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpointsCancer Res.63,31-35(2003)
Kawabe, T.G2 checkpoint abrogators as anticancer drugsMol. Cancer Ther.3(4),513-519(2004)
