Fasudil Hydrochloride
Cat. No.：YN310062
| 产品名称: | Fasudil Hydrochloride |
| CAS No.: | 105628-07-7 |
| Chemical Name: | 5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]isoquinoline Hydrochloride; Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine Monohydrochloride; 1-(5-Isoquinolinesulfonyl)homopiperazine Hydrochloride; Eril; |
| Synonyms: | 盐酸法舒地尔; HA-1077 Hydrochloride; AT-877 Hydrochloride |
| 分子量: | 327.83 |
| 分子式: | C₁₄H₁₈ClN₃O₂S |
| SMILES: | O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3)=O.Cl[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fasudil Hydrochloride (HA-1077 Hydrochloride; AT877 Hydrochloride) 是一种非特异性ROCK抑制剂，对蛋白激酶也有抑制作用，ROCK1 的Ki值为 0.33 μM，ROCK2 和 PKA，PKC，PKG 的IC50值分别 0.158 μM 和 4.58 μM，12.30 μM，1.650 μM。Fasudil Hydrochloride 也是一种有效的 Ca2+通道拮抗剂和血管扩张剂。 |
| IC50和靶点: | [{name:"p160ROCK:0.33 μM (Ki)"},{name: "ROCK2:0.158 μM (IC50)"},{name: "PKA:4.58 μM (IC50)"},{name: "PKC:12.30 μM (IC50)"},{name: "PKG:1.65 μM (IC50)"}] |
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| Solvent & Solubility: |
Kanazawa, I., et al.: Endocr. J., 57, 415-421 (2010)
Ding, J., et al.: J. Neurochem., 114, 1619-1629 (2010)
Li, Y., et al.: Med. Sci. Monit., 16, BR112-BR118 (2010)
Fujimura, M., et al.: Toxicol. Appl. Pharmacol., 250, 1-9 (2011)
