Fasudil
Cat. No.：YN310063
| 产品名称: | Fasudil |
| CAS No.: | 103745-39-7 |
| Chemical Name: | |
| Synonyms: | 法舒地尔; HA-1077; AT877 |
| 分子量: | 291.37 |
| 分子式: | C₁₄H₁₇N₃O₂S |
| SMILES: | O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fasudil (HA-1077; AT877) 是一种非特异性ROCK抑制剂，对蛋白激酶也有抑制作用，ROCK1 的Ki值为 0.33 μM，ROCK2 和 PKA，PKC，PKG 的IC50值分别 0.158 μM 和 4.58 μM，12.30 μM，1.650 μM。Fasudil 也是一种有效的 Ca2+通道拮抗剂和血管扩张剂。 |
| IC50和靶点: | [{name:"p160ROCK:0.33 μM (Ki)"},{name: "ROCK2:0.158 μM (IC50)"},{name: "PKA:4.58 μM (IC50)"},{name: "PKC:12.3 μM (IC50)"},{name: "PKG:1.65 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
