Enzastaurin
Cat. No.：YN310064
CAS No. ：170364-57-5
| 产品名称: | Enzastaurin |
| CAS No.: | 170364-57-5 |
| Chemical Name: | 3-(1-methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione |
| Synonyms: | 恩扎妥林; LY317615 |
| 分子量: | 515.61 |
| 分子式: | C₃₂H₂₉N₅O₂ |
| SMILES: | O=C(C(C1=CN(C)C2=C1C=CC=C2)=C3C4=CN(C5CCN(CC6=NC=CC=C6)CC5)C7=C4C=CC=C7)NC3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Enzastaurin (LY317615) 是一种有效的PKCβ抑制剂，IC50值为 6 nM。Enzastaurin 对 PKCβ 选择性是 PKCα，PKCγ 和 PKCε 的 6-20 倍。 |
| IC50和靶点: | [{name:"PKCβ:6 nM (IC50)"},{name: "PKCα:39 nM (IC50)"},{name: "PKCγ:83 nM (IC50)"},{name: "PKCε:110 nM (IC50)"}] |
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Graff, J.R., McNulty, A.M., Hanna, K.R., et al.The protein kinase Cβ-selective inhibitor, enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenograftsCancer Res.65(16),7462-7469(2005)
Querfeld, C., Rizvi, M.A., Kuzel, T.M., et al.The selective protein kinase C β inhibitor enzastaurin induces apoptosis in cutaneous T-cell lymphoma cell lines through the AKT pathwayJ. Invest. Dermatol.126(7),1641-1647(2006)
Herbst, R.S., Oh, Y., Wagle, A., et al.Enzastaurin, a protein kinase Cβ-selective inhibitor, and its potential application as an anticancer agent in lung cancerClin. Cancer Res.13(15.2),s4641-s4646(2007)
