Sotrastaurin
Cat. No.：YN310065
| 产品名称: | Sotrastaurin |
| CAS No.: | 425637-18-9 |
| Chemical Name: | 3-(1H-indol-3-yl)-4-[2-(4-methyl-1-piperazinyl)-4-quinazolinyl]-1H-pyrrole-2,5-dione |
| Synonyms: | AEB071 |
| 分子量: | 438.48 |
| 分子式: | C₂₅H₂₂N₆O₂ |
| SMILES: | O=C(C(C1=C2C=CC=CC2=NC(N3CCN(C)CC3)=N1)=C4C5=CNC6=C5C=CC=C6)NC4=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sotrastaurin (AEB071) 是一种口服有效的 pan-PKC抑制剂，作用于 PKCθ，PKCβ，PKCα，PKCη，PKCδ 和 PKCε，Ki分别为 0.22 nM，0.64 nM，0.95 nM，1.8 nM，2.1 nM 和 3.2 nM。 |
| IC50和靶点: | [{name:"PKCθ:0.22 nM (Ki)"},{name: "PKCβI:0.64 nM (Ki)"},{name: "PKCα:0.95 nM (Ki)"},{name: "PKCη:1.8 nM (Ki)"},{name: "PKCδ:2.1 nM (Ki)"},{name: "PKCε:3.2 nM (Ki)"}] |
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Evenou, J.P., Wagner, J., Zenke, G., et al.The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activationJ. Pharmacol. Exp. Ther.330(3),792-801(2009)
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Verkaar, F., van der Stelt, M., Blankesteijn, W.M., et al.Discovery of novel small molecule activators of β-catenin signalingPLoS One6(4),e19185(2011)
