ULS 欢迎您!
ULS 欢迎您!
> 产品中心 > 抑制剂 & 激动剂 > TGF-beta/Smad > PKC

Bryostatin 1

Cat. No.:YN310074

  • CAS No. :83314-01-6

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: Bryostatin 1
      CAS No.: 83314-01-6
      Chemical Name: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E,4E)-2,4
      Synonyms:苔藓抑素1
      分子量:905.03
      分子式:C₄₇H₆₈O₁₇
      SMILES:O[C@]12[C@H](/C(C[C@](C[C@](OC(C[C@@H](C[C@@]3([H])O[C@](O)(C(C)([C@@H](OC(C)=O)C3)C)C[C@@](C/4)([H])O[C@@](CC4=C/C(OC)=O)([H])/C=C/C2(C)C)O)=O)([H])[C@H](O)C)([H])O1)=C/C(OC)=O)OC(/C=C/C=C/CCC)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: Bryostatin 1 是一种天然的大环内酯类化合物,从苔藓虫Bugula neritina中分离出来,也是一种有效的中枢神经系统 (CNS) 渗透性的PKC调节剂。Bryostatin 1 以Ki值为 8.07 nM 和 0.45 nM 分别结合到分离的 Munc13-1 的 C1 域和全长的 Munc13-1 蛋白。Bryostatin 1 具有抗癌,抗炎,神经保护,抗HIV-1感染的特性。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Abramson, E., Hardman, C., Shimizu, A.J., et al.Designed PKC-targeting bryostatin analogs modulate innate immunity and neuroinflammationCell. Chem. Biol.28(4),537-545(2021)

      Kortmansky, J., and Schwartz, G.K.Bryostatin-1: A novel PKC inhibitor in clinical developmentCancer Invest.21(6),924-936(2003)

      Hany, L., Turmel, M.-O., Barat, C., et al.Bryostatin-1 decreases HIV-1 infection and viral production in human primary macrophagesJ. Virol.96(4),e0195321(2022)

      Kornberg, M.D., Smith, M.D., Shirazi, H.A., et al.Bryostatin-1 alleviates experimental multiple sclerosisProc. Natl. Acad. Sci. U.S.A.115(9),2186-2191(2018)

      Lucke-Wold, B.P., Logsdon, A.F., Smith, K.E., et al.Bryostatin-1 restores blood brain barrier integrity following blast-induced traumatic brain injuryMol. Neurobiol.52(3),1119-1134(2015)

    • 摩尔计算器
    • 稀释计算器
    摩尔浓度计算器方程 :
    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    计算

    质量 浓度 体积 分子量
    稀释计算器 :
    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
    • C1
      V1
      C2
      V2
    • 您最近查看的产品:
    相关产品


    ULS 的所有产品和服务仅用于科学研究,我们不为任何其他用途提供产品和服务(也不为任何个人提供产品和服务)Copyright © 2020-2021 ULS. All Rights Reserved. 备案号:粤ICP备2021013238号-1
    0.322363s