SB-218078
Cat. No.：YN310080
| 产品名称: | SB-218078 |
| CAS No.: | 135897-06-2 |
| Chemical Name: | 9,10,11,12-tetrahydro-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione |
| Synonyms: | SB 218078,SB-218078 |
| 分子量: | 393.39 |
| 分子式: | C₂₄H₁₅N₃O₃ |
| SMILES: | O=C1NC(C(C2=C3N(C4CCC5O4)C6=CC=CC=C62)=C1C7=C3N5C8=CC=CC=C78)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SB-218078 是一种有效的，选择性，ATP 竞争性且细胞可渗透的检查点激酶 1 (Chk1) 抑制剂，可抑制 cdc25C 的Chk1磷酸化，IC50为 15 nM。SB-218078 对Cdc2(IC50为 250 nM) 和PKC(IC50为 1000 nM) 的抑制作用较弱。SB-218078 通过 DNA 损伤和细胞周期停滞诱导细胞凋亡。 |
| IC50和靶点: | [{name:"Chk1:15 nM (IC50)"},{name: "Cdc2:250 nM (IC50)"},{name: "PKC:1000 nM (IC50)'}, 'Apoptosis'] |
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Jackson, J.R., Gilmartin, A., Imburgia, G., et al.An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damageCancer Res.60(3),566-572(2000)
Tandon, M., Johnson, J., Li, Z., et al.New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cellsPLoS One8(9),e75601(2013)
Kawabe, T.G2 checkpoint abrogators as anticancer drugsMol. Cancer Ther.3(4),513-519(2004)
