R 59-022
Cat. No.：YN310085
| 产品名称: | R 59-022 |
| CAS No.: | 93076-89-2 |
| Chemical Name: | 6-[2-[4-[(4-fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one |
| Synonyms: | DKGI-I; Diacylglycerol kinase inhibitor I |
| 分子量: | 459.58 |
| 分子式: | C₂₇H₂₆FN₃OS |
| SMILES: | O=C1C(CCN(CC/2)CCC2=C(C3=CC=CC=C3)/C4=CC=C(F)C=C4)=C(C)N=C5N1C=CS5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | R 59-022 (DKGI-I) 是一种二酰甘油激酶 (diacylglycerol kinase) 抑制剂 (IC50=2.8 μM)。R 59-022 是一种5-HTR拮抗剂，激活蛋白激酶 C(PKC)。R 59-022 增强凝血酶诱导血小板产生二酰甘油和抑制中性粒细胞产生磷脂酸。 |
| IC50和靶点: | |
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Dominguez, C.L., Floyd, D.H., Xiao, A., et al.Diacylglycerol kinase a is a critical signaling node and novel therapeutic target in glioblastoma and other cancersCancer Discov.3(7),782-797(2013)
Tu-Sekine, B., Goldschmidt, H., Petro, E., et al.Diacylglycerol kinase θ: Regulation and stabilityAdv. Biol. Regul.53(1),118-126(2013)
Gómez-Merino, F.C., Arana-Ceballos, F.A., Trejo-Téllez, L.I., et al.Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases (DGKs), displays unique biochemical features and saturates at low substrate concentration: The DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro and alters plant growth and developmentJ. Biol. Chem.280(41),34888-34899(2005)
