Bisindolylmaleimide X hydrochloride
Cat. No.：YN310087
| 产品名称: | Bisindolylmaleimide X hydrochloride |
| CAS No.: | 145317-11-9 |
| Chemical Name: | 3-[8-(aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione, monohydrochloride |
| Synonyms: | BIM-X hydrochloride; Ro31-8425 hydrochloride |
| 分子量: | 460.96 |
| 分子式: | C₂₆H₂₅ClN₄O₂ |
| SMILES: | O=C(C(C1=C(CC(CN)CC2)N2C3=C1C=CC=C3)=C4C5=CN(C)C6=C5C=CC=C6)NC4=O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) 是一种有效的，选择性的蛋白激酶 C (PKC) 抑制剂。Bisindolylmaleimide X hydrochloride 也是一种有效的细胞周期蛋白依赖性激酶 2 (CDK2) 拮抗剂，IC50为 200 nM。 |
| IC50和靶点: | [{name:"CDK2:200 nM (IC50)'}, 'PKC'] |
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Wilkinson, S.E., Parker, P.J., and Nixon, J.S.Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase CBiochem. J.294(Pt 2),335-337(1993)
Brehmer, D., Godl, K., Zech, B., et al.Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitorsMol. Cell. Proteomics3(5),490-500(2004)
Levy, O., Mortensen, L.J., Boquet, G., et al.A small-molecule screen for enhanced homing of systemically infused cellsCell Rep.10(8),1261-1268(2015)
