Bisindolylmaleimide IV
Cat. No.：YN310088
CAS No. ：119139-23-0
| 产品名称: | Bisindolylmaleimide IV |
| CAS No.: | 119139-23-0 |
| Chemical Name: | 3,4-di-1H-indol-3-yl-1H-pyrrole-2,5-dione |
| Synonyms: | Arcyriarubin A |
| 分子量: | 327.34 |
| 分子式: | C₂₀H₁₃N₃O₂ |
| SMILES: | O=C(C(C1=CNC2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bisindolylmaleimide IV (Arcyriarubin A) 是一种有效的蛋白激酶 C(PKC)抑制剂，其IC50范围为 0.1-0.55 μM。Bisindolylmaleimide IV 也抑制 PKA (IC50=3.1-11.8 μM)。Bisindolylmaleimide IV 在细胞培养中，是有效的人巨细胞病毒(HCMV)复制的抑制剂，IC50为 0.2 μM。 |
| IC50和靶点: | [{name:"PKC:0.1-0.55 μM (IC50)"},{name: "HCMV:0.2 μM (IC50)"}] |
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Davis, P.D., Hill, C.H., Lawton, G., et al.Inhibitors of protein kinase C. 1.1 2,3-bisarylmaleimidesJ. Med. Chem.35(1),177-184(1992)
Toullec, D., Pianetti, P., Coste, H., et al.The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase CJ. Biol. Chem.266(24),15771-15781(1991)
Fabre, S., and Prudhomme, M.Protein kinase C inhibitors; structure-activity relationships in K252c-related compoundsBioorg. Med. Chem.1(3),193-196(1993)
Lazareno, S., Popham, A., and Birdsall, N.J.M.Muscarinic interactions of bisindolylmaleimide analoguesEur. J. Pharmacol.360(2-3),281-284(1998)
