UCN-02
Cat. No.：YN310089
| 产品名称: | UCN-02 |
| CAS No.: | 121569-61-7 |
| Chemical Name: | (3S,9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one |
| Synonyms: | 7-epi-Hydroxystaurosporine |
| 分子量: | 482.53 |
| 分子式: | C₂₈H₂₆N₄O₄ |
| SMILES: | O=C1C2=C([C@H](O)N1)C3=C(N4C5=C3C=CC=C5)C6=C2C7=CC=CC=C7N6[C@]8([H])O[C@@]4(C)[C@H](OC)[C@H](NC)C8 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | UCN-02 (7-epi-Hydroxystaurosporine) 是一种由链霉菌属 N-126 菌株产生的，选择性的蛋白激酶 C(PKC)抑制剂，对 PKC 和 PKA 作用的IC50值分别为 62 nM 和 250 nM。 UCN-02 对 HeLa S3 细胞具有细胞毒性，能抑制其生长。 |
| IC50和靶点: | |
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Takahashi, I., Saitoh, Y., Yoshida, M., et al.UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activitiesJ. Antibiot. (Tokyo)42(4),571-576(1989)
