TCS 21311
Cat. No.：YN310090
CAS No. ：1260181-14-3
| 产品名称: | TCS 21311 |
| CAS No.: | 1260181-14-3 |
| Chemical Name: | 3-[5-[4-(2-hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Synonyms: | NIBR3049 |
| 分子量: | 526.51 |
| 分子式: | C₂₇H₂₅F₃N₄O₄ |
| SMILES: | O=C(C(C1=CC(N2CCN(C(C(C)(O)C)=O)CC2)=CC=C1C(F)(F)F)=C3C4=CNC5=C4C=CC=C5)NC3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TCS 21311 (NIBR3049) 是一种有效的高选择性JAK3抑制剂，其IC50为 8 nM，它的选择性是 JAK1，JAK2 和 TYK2 的100倍以上。TCS 21311 (NIBR3049) 抑制PKCα，PKCθ和GSK3β，IC50值分别为 13、68 和 3 nM。 |
| IC50和靶点: | [{name:"JAK3:8 nM (IC50)"},{name: "JAK2:2.55 μM (IC50)"},{name: "JAK1:1.017 μM (IC50)"},{name: "PKCα:13 nM (IC50)"},{name: "PKCθ:68 nM (IC50)"},{name: "GSK-3β:3 nM (IC50)"}] |
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| Solvent & Solubility: |
Thoma, G., Nuninger, F., Falchetto, R., et al.Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase familyJ. Med. Chem.54(1),284-288(2011)
Tsujimoto, H., Araoka, T., Nishi, Y., et al.Small molecule TCS21311 can replace BMP7 and facilitate cell proliferation in in vitro expansion culture of nephron progenitor cellsBiochem. Biophys. Res. Commun.,(2020)
