O-Desmethyl Midostaurin
Cat. No.：YN310201
| 产品名称: | O-Desmethyl Midostaurin |
| CAS No.: | 740816-86-8 |
| Chemical Name: | N-[(9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methylbenzamide; CGP 62221; O-Desmethyl-PKC 412 |
| Synonyms: | CGP62221; O-Desmethyl PKC412 |
| 分子量: | 556.61 |
| 分子式: | C₃₄H₂₈N₄O₄ |
| SMILES: | O=C(N([C@@H]1C[C@]([H])(N2C3=C4C=CC=C3)O[C@](C)(N5C6=C2C4=C(C(NC7)=O)C7=C6C8=C5C=CC=C8)[C@@H]1O)C)C9=CC=CC=C9 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) 是 Midostaurin (HY-10230) 的活性代谢物，通过细胞色素 P450 肝酶代谢产生，可以作为 Midostaurin 在体内代谢的指标之一。Midostaurin 是一种多靶点蛋白激酶 (kinase) 抑制剂，IC50范围为 22-500 nM。 |
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Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012)
Pedeboscq, S., et al.: PLoS. One., 7, 36811 (2012)
