Ionomycin
Cat. No.：YN310216
CAS No. ：56092-81-0
| 产品名称: | Ionomycin |
| CAS No.: | 56092-81-0 |
| Chemical Name: | (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid |
| Synonyms: | SQ23377 |
| 分子量: | 709.01 |
| 分子式: | C₄₁H₇₂O₉ |
| SMILES: | O=C(O)CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C(O)/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@@H]2O[C@](C)([C@H](O)C)CC2)(C)O1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ionomycin (SQ23377) 是一种有效的，选择性的钙离子载体(calcium ionophore)，也是一种由Streptomyces conglobatus产生的抗生素。Ionomycin (SQ23377) 对二价阳离子具有高度特异性 (Ca>Mg>Sr=Ba)。Ionomycin (SQ23377) 促进细胞凋亡。Ionomycin (SQ23377) 还诱导蛋白激酶C (PKC) 激活。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Liu, W.C., Slusarchyk, D.S., Astle, G., et al.Ionomycin, a new polyether antibioticJ. Antibiot. (Tokyo)31(9),815-819(1978)
Locke, M., Francis, R.J., Tsaousi, E., et al.Fibrinogen protects neutrophils from the cytotoxic effects of histones and delays neutrophil extracellular trap formation induced by ionomycinSci. Rep.10(1),11694(2020)
Lehnert, C., Weiswange, M., Jeremias, I., et al.TRAIL-receptor costimulation inhibits proximal TCR signaling and suppresses human T cell activation and proliferationJ. Immunol.193(8),4021-4031(2014)
Foey, A.D., and Brennan, F.M.Conventional protein kinase C and atypical protein kinase Cζ differentially regulate macrophage production of tumour necrosis factor-ɑ and interleukin-10Immunology112(1),44-53(2004)
