Mitoxantrone dihydrochloride
Cat. No.：YN310219
| 产品名称: | Mitoxantrone dihydrochloride |
| CAS No.: | 70476-82-3 |
| Chemical Name: | 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione, dihydrochloride |
| Synonyms: | 米托蒽醌二盐酸盐; mitozantrone dihydrochloride |
| 分子量: | 517.40 |
| 分子式: | C₂₂H₃₀Cl₂N₄O₆ |
| SMILES: | O=C1C2=C(C(NCCNCCO)=CC=C2NCCNCCO)C(C3=C(O)C=CC(O)=C13)=O.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Mitoxantrone dihydrochloride是拓扑异构酶II (topoisomerase II)的抑制剂；也可抑制蛋白激酶C (PKC)，IC50值为8.5 μM。 |
| IC50和靶点: | [{name:"PKC:8.5 μM (IC50)'}, 'Topoisomerase II'] |
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Carlson, H.A., Masukawa, K.M., Rubins, K., et al.Developing a dynamic pharmacophore model for HIV-1 integraseJ. Med. Chem.43(111),2100-2114(2000)
Fox, M.E., and Smith, P.J.Long-term inhibition of DNA synthesis and the persistence of trapped topoisomerase II complexes in determining the toxicity of the antitumor DNA intercalators mAMSA and mitoxantroneCancer Res.50(18),5813-5818(1990)
Zhang, Q., Radvak, P., Lee, J., et al.Mitoxantrone modulates a heparan sulfate-spike complex to inhibit SARS-CoV-2 infectionSci. Rep.12(1),6294(2022)
