Go 6983
Cat. No.：YN310237
CAS No. ：133053-19-7
| 产品名称: | Go 6983 |
| CAS No.: | 133053-19-7 |
| Chemical Name: | 3-[1-[3-(dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Synonyms: | Gö 6983; Goe 6983 |
| 分子量: | 442.51 |
| 分子式: | C₂₆H₂₆N₄O₃ |
| SMILES: | O=C(C(C1=CN(CCCN(C)C)C2=C1C=C(OC)C=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Go 6983 是一种有效的PKC抑制剂，能够作用于PKCα，PKCβ，PKCγ，PKCδ和PKCζ，IC50值分别为 7 nM，7 nM，6 nM，10 nM 和 60 nM。 |
| IC50和靶点: | [{name:"PKCγ:6 nM (IC50)"},{name: "PKCα:7 nM (IC50)"},{name: "PKCβ:7 nM (IC50)"},{name: "PKCδ:10 nM (IC50)"},{name: "PKCζ:60 nM (IC50)"},{name: "PKCμ:20000 nM (IC50)"}] |
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| Solvent & Solubility: |
Gschwendt, M., Dieterich, S., Rennecke, J., et al.Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase c isoenzymesFEBS Lett.392,77-80(1996)
Peterman, E.E., Taormina, P., II, Harvey, M., et al.Gö 6983 exerts cardioprotective effects in myocardial ischemia/reperfusionJ. Biomed. Sci.43,645-656(2004)
Young, L.H., Balin, B.J., and Weis, M.T.Gö 6983: A fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injuryCardiovasc. Drug Rev.23(3),255-272(2005)
