Ro 31-8220 mesylate
Cat. No.：YN310249
| 产品名称: | Ro 31-8220 mesylate |
| CAS No.: | 138489-18-6 |
| Chemical Name: | carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester, monomethanesulfonate |
| Synonyms: | Ro 31-8220 methanesulfonate; Bisindolylmaleimide IX mesylate |
| 分子量: | 553.65 |
| 分子式: | C₂₆H₂₇N₅O₅S₂ |
| SMILES: | NC(SCCCN1C=C(C2=C(C3=CN(C)C4=C3C=CC=C4)C(NC2=O)=O)C5=C1C=CC=C5)=N.CS(=O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ro 31-8220 mesylate 是一种有效的PKC抑制剂，抑制 PKCα，PKCβI，PKCβII，PKCγ，PKCε 和大鼠大脑 PKC 的IC50值为 5，24，14，27，24 和 23 nM，也可抑制 MAPKAP-K1b，MSK1，S6K1 和 GSK3β，IC50为3，8，15，38 nM。 |
| IC50和靶点: | [{name:"PKC-α:5 nM (IC50)"},{name: "PKC-βI:24 nM (IC50)"},{name: "PKC-βII:14 nM (IC50)"},{name: "PKC-γ:27 nM (IC50)"},{name: "PKC-ε:24 nM (IC50)"},{name: "Rat Brain PKC:23 nM (IC50)"},{name: "MAPKAP-K1b:3 nM (IC50)"},{name: "MSK1:8 nM (IC50)"},{name: "S6K1:15 nM (IC50)"},{name: "GSK3β:38 nM (IC50)"}] |
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Wilkinson, S.E., Parker, P.J., and Nixon, J.S.Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase CBiochem. J.294(Pt 2),335-337(1993)
Hers, I., Tavaré, J.M., and Denton, R.M.The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activityFEBS Lett.460(3),433-436(1999)
