Ro 31-8220
Cat. No.：YN310250
| 产品名称: | Ro 31-8220 |
| CAS No.: | 125314-64-9 |
| Chemical Name: | |
| Synonyms: | Bisindolylmaleimide IX |
| 分子量: | 457.55 |
| 分子式: | C₂₅H₂₃N₅O₂S |
| SMILES: | NC(SCCCN1C=C(C2=C(C3=CN(C)C4=C3C=CC=C4)C(NC2=O)=O)C5=C1C=CC=C5)=N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ro 31-8220 是一种有效的PKC抑制剂，对 PKCα，PKCβI，PKCβII，PKCγ，PKCε 和大鼠大脑 PKC 的IC50值为 5，24，14，27，24 和 23 nM，同时能够有效抑制 MAPKAP-K1b，MSK1，S6K1 和 GSK3β (IC50，3，8，15，38 nM), 对 MKK3，MKK4，MKK6 和 MKK7 无作用。 |
| IC50和靶点: | [{name:"PKC-α:5 nM (IC50)"},{name: "PKC-βII:14 nM (IC50)"},{name: "PKC-βI:24 nM (IC50)"},{name: "PKC-ε:24 nM (IC50)"},{name: "PKC-γ:27 nM (IC50)"},{name: "Rat Brain PKC:23 nM (IC50)"},{name: "MAPKAP-K1b:3 nM (IC50)"},{name: "MSK1:8 nM (IC50)"},{name: "S6K1:15 nM (IC50)"},{name: "GSK3β:38 nM (IC50)"}] |
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